THE 13th Sugiyama Laboratory Open Symposium
“New challenges for in vitro and in vivo extrapolations with regard to DDI and clearance estimation; Albumin effect and critical scaling factors”
Date : Feb 22 (Fri) 13：00-17：35 , 2019
Place : RIKEN Yokohama Main Building Hall
Language：English
Registration Fee : Free
Banquet fee: \ 3,000 17:45-19:20
Registration ; mail to yslab.secretary [at] ml.riken.jp with below information.
name/affiliation/mail address/banquet(attend or not)
※ no later than Feb. 1st, 2019 Japan time
※ We will inform all participants about the password for viewing abstract.
This Symposium is a part of the RIKEN Symposium Series.
Abstract
Program
13:00-13:05 Opening remarks
Yuichi Sugiyama (Sugiyama Laboratory, RIKEN)
13:05-14:00 【Plenary lecture】
Visomedigib and Venetoclax: Approved Drugs with Unique
Pharmacokinetic
Properties
Cornelis “Marcel” Hop (Genentech inc.)
14:00-14:35 Development of Orthogonal Linear Separation Analysis (OLSA) to
Decompose Pharmacological Effect and Extract Elementary Ones.
Hiroyuki Kusuhara (The University of Tokyo / RIKEN)
14:35-15:05 PBPK model of rifampicin as a perpetrator integrating bottom-up
and top-down approaches.
Ryuta Asaumi (Ono Pharmaceutical Co., Ltd.)
15:05-15:25 Coffee break
15:25-15:55 Analysis of drug-drug interactions of pitavastatin and rosuvastatin
with oral or intravenous administration of rifampicin using PBPK
models.
Mayuko Miyagawa (Astellas Pharma Inc.)
15:55-16:25 Application of PBPK modeling to renal OCT2 and MATEs mediated
DDIs: Predicting changes in renal clearance and blood AUC caused by
the transporter inhibitors.
Kotaro Nishiyama (Nippon Boehringer Ingelheim Co., Ltd.)
16:25-16:55 In vitro and in vivo extrapolation of hepatic uptake clearances for
drugs with high protein binding accounted for the "albumin
mediated" hepatic uptake mechanism.
Seiji Miyauchi (Toho University / RIKEN)
16:55-17:35 General Discussion
Yuichi Sugiyama (Sugiyama Laboratory, RIKEN)
17:45-19:20 Banquet (Cafeteria at Yokohama RIKEN)
Contact to：Sugiyama's Laboratory
Email: yslab.secretary [at] ml.riken.jp
HP: http://www.sugiyamalab.com/
Tel: 045‐503‐9210