The 6th Sugiyama Laboratory Open Symposium

13:20-13:30

Opening Remarks
Yuichi Sugiyama (Head of Sugiyama Laboratory, RIKEN Innovation Center)

13:30-14:25

【Primary Lecture】 Frontiers in Systems Drug Design
Hiroaki Kitano (The Systems Biology Institute / Laboratory for Disease Systems Modeling, RIKEN/IMS)

14:25-15:00

Systems-biology as a tool to predict drug-induced toxicity
Hiroshi Suzuki （The University of Tokyo Hospital, Faculty of Medicine,
The University of Tokyo, Professor）

Coffee Break / Recess

15:20-15:50

Phramacokinetic modeling and Monte Carlo simulation to predict inter-individual variability of human exposure for oseltamivir and its active metabolite, Ro64-0802
Mototsugu Ito（CP Science & Operations Group, Clinical Pharmacology Global
Development Astellas Pharma Inc.）

15:50-16:25

Development of theoretical insight and methods to determine the Kpuu value (Liver-to-plasma unbound concentration ratio) of drugs of which drug distribution and clearance is governed by active transporters.
Yuichi Sugiyama（Head of Sugiyama Laboratory, RIKEN Innovation Center）

16:25-16:55 

Prediction of drug interactions using endogenous compounds; importance of
pharmacokinetic model
Hiroyuki Kusuhara （Graduate School of Pharmaceutical Sciences, The University of Tokyo, Professor) 

16:55-17:25

A mathematical approach to propose a more discriminatory bioequivalence analysis for liposomal drugs
Jin‐ding Huang（National C heng Kung University, Professor, Taiwan）

17:25-18:10

Roundtable Discussion

18:20-19:40

Banquet （Cafeteria at Yokohama RIKEN） *Fee: 3,000yen