THE 7th Sugiyama Laboratory Open Symposium
New paradigm for the precise prediction of inter-individual differences and drug interactions of new drug candidates
Date: February 16 (Tuesday) 13:50－18:00, 2016
Place: RIKEN Yokohama Main Building Hall Access
Language：English
Registration Fee: Symposium Free, banquet 3,000yen
Registration:Nov 18 (wed) ,2015~ Jan 29 (Fri),2016 Japan time
This Symposium is a part of the RIKEN Symposium Series.
The 7th Sugiyama Laboratory Open Symposium has successfully finished.
We would like to thank all participants.
Program
13:50-14:00 Opening Remarks
Yuichi Sugiyama（Head of Sugiyama Laboratory, RIKEN Innovation Center）
14:00-14:35 Proposal of the methods for estimating important parameters (cell to medium unbound concentration ratio(Kpuu), ratio of passive to active transport, ratio of biliary excretion clearance to metabolic clearance) in the PBPK modeling
Yuichi Sugiyama（Head of Sugiyama Laboratory, RIKEN Innovation Center）
14:35-15:05 Can "free drug theory" feasibly evaluate the hepatic uptake clearance of a drug with highly protein binding?
Seiji Miyauchi（Toho University/RIKEN）
15:05-15:35 Analysis of drug interaction mechanism in humans based on PBPK model: A case study for eltrombopag
Yukio Kato（Kanazawa University/RIKEN）
15:35-15:55 Coffee Break 20分
15:55-16:25 Current Status and Future Challenges of the Prediction of Pharmacokinetic Alterations in Special Population
Kazuya Maeda (The University of Tokyo/RIKEN)
16:25-16:55 Effect of CYP3A5 Expression on the Inhibition of CYP3A-Catalyzed Drug Metabolism: Impact on Modeling CYP3A-Mediated Drug-Drug Interactions
Yoshiyuki Shirasaka (Tokyo University of Pharmacy and Life Sciences)
16:55-17:25 Theoretical framework of oral drug absorption
Kiyohiko Sugano（Toho University）
17:25-18:00 General Discussion
18:10-19:40 Banquet （Cafeteria at Yokohama RIKEN） *fee 3,000yen
Contact to：Sugiyama's Laboratory
Email: info [at] riken‐sugiyama.jp
HP: http://www.sugiyamalab.com/
Tel: 045‐503‐9210