THE 7th Sugiyama Laboratory Open Symposium

New paradigm for the precise prediction of inter-individual differences and drug interactions of new drug candidates

Date: February 16 (Tuesday) 13:50-18:00, 2016

Place: RIKEN Yokohama Main Building Hall  Access


Registration Fee: Symposium Free, banquet 3,000yen


Registration:Nov 18 (wed) ,2015~ Jan 29 (Fri),2016 Japan time




This Symposium is a part of the RIKEN Symposium Series.


The 7th Sugiyama Laboratory Open Symposium has successfully finished.  

We would like to thank all participants.



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13:50-14:00        Opening Remarks

                          Yuichi SugiyamaHead of Sugiyama Laboratory, RIKEN Innovation Center


14:00-14:35        Proposal of the methods for estimating important parameters (cell to medium unbound concentration ratio(Kpuu), ratio of passive to active transport, ratio of biliary excretion clearance to metabolic clearance) in the PBPK modeling

                          Yuichi SugiyamaHead of Sugiyama Laboratory, RIKEN Innovation Center) 


14:35-15:05        Can "free drug theory" feasibly evaluate the hepatic uptake clearance of a drug with highly protein binding?

                          Seiji MiyauchiToho University/RIKEN) 


15:05-15:35        Analysis of drug interaction mechanism in humans based on PBPK model: A case study for eltrombopag

                          Yukio KatoKanazawa University/RIKEN


15:35-15:55        Coffee Break 20


15:55-16:25        Current Status and Future Challenges of the Prediction of Pharmacokinetic Alterations in Special Population

                          Kazuya Maeda (The University of Tokyo/RIKEN)


16:25-16:55        Effect of CYP3A5 Expression on the Inhibition of CYP3A-Catalyzed Drug Metabolism: Impact on Modeling CYP3A-Mediated Drug-Drug Interactions

                          Yoshiyuki Shirasaka (Tokyo University of Pharmacy and Life Sciences)


16:55-17:25        Theoretical framework of oral drug absorption

                          Kiyohiko SuganoToho University


17:25-18:00        General Discussion


18:10-19:40        Banquet (Cafeteria at Yokohama RIKEN) *fee 3,000yen

Contact to:Sugiyama's Laboratory
Email: info [at] riken‐
Tel: 045‐503‐9210