THE 8th Sugiyama Laboratory Open Symposium
“Exploring new approaches for improving the accuracy of pharmacokinetic prediction of new drug candidates”

Date:Oct 17 13:50-18:30, 2016
Place: RIKEN Yokohama Main Building Hall Access
Language:English
Registration Fee: Symposium Free, banquet 3,000yen
Registration url; https://riken-sugiyama.jp/form.8th/ja/
The 8th Sugiyama Laboratory Open Symposium has successfully finished.
We would like to thank all participants.
This Symposium is a part of the RIKEN Symposium Series.
Program
13:50-14:00 |
Opening remarks Yuichi Sugiyama (Sugiyama Laboratory, RIKEN Innovation Center) |
14:00-14:45 |
Differential impact of hypoxia on cancer-type vs liver-type variants of organic aniontransporting polypeptide 1B3 (OATP1B3) Wooin Lee (Seoul National University) |
14:45-15:25 |
Does a mechanism of albumin-mediated hepatic uptake of organic anions account for the discrepancy of hepatic clearance between in vitro and in vivo? Yuichi Sugiyama (Sugiyama Laboratory, RIKEN Innovation Center) |
15:25-15:55 |
Analysis of nonlinear pharmacokinetics of highly albumin-bound compound Yukina Fukuchi (Ono Pharmaceutical Co., Ltd.) |
15:55-16:15 |
Coffee break |
16:15-16:45 |
Transporter targeted proteomics: applications and limitations Kimoto Emi (Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc.)
|
16:45-17:15 |
Prediction of Kp,uu of organic anions in hepatocytes considering the effect of the membrane potential Takashi Yoshikado (Sugiyama Laboratory, RIKEN Innovation Center) |
17:15-17:45 |
Potential of computer based “Virtual Clinical Study”; physiologically-based pharmacokinetic modeling for CPT-11 and its metabolites as a model case Kota Toshimoto (Sugiyama Laboratory, RIKEN Innovation Center) |
17:45-18:15 |
Precise estimation of fm and Ki values for the prediction of CYP-mediate drug interactions by the use of Cluster Newton Method Kazuya Maeda (The University of Tokyo) |
18:15-18:30 |
Concluding remarks Yuichi Sugiyama (Sugiyama Laboratory, RIKEN Innovation Center) |
18:30-20:00 |
Banquet (Cafeteria at Yokohama RIKEN) |
Contact to:Sugiyama's Laboratory
Email: info [at] riken‐sugiyama.jp
HP: http://www.sugiyamalab.com/
Tel: 045‐503‐9210