THE 8th Sugiyama Laboratory Open Symposium

“Exploring new approaches for improving the accuracy of pharmacokinetic prediction of new drug candidates”

Date:Oct 17 13:50-18:30, 2016

Place: RIKEN Yokohama Main Building Hall  Access

Language:English

Registration Fee: Symposium Free, banquet 3,000yen

 

Registration url; https://riken-sugiyama.jp/form.8th/ja/

 

 

The 8th Sugiyama Laboratory Open Symposium has successfully finished.  

We would like to thank all participants.

 

 

This Symposium is a part of the RIKEN Symposium Series.

Program

program
the 8th Symposiumu program.pdf
PDFファイル 154.2 KB

 

13:50-14:00

Opening remarks

 Yuichi Sugiyama (Sugiyama Laboratory, RIKEN Innovation Center) 

14:00-14:45

Differential impact of hypoxia on cancer-type vs liver-type variants of organic aniontransporting polypeptide 1B3 (OATP1B3)

 Wooin Lee (Seoul National University)

14:45-15:25

Does a mechanism of albumin-mediated hepatic uptake of organic anions account for the

discrepancy of hepatic clearance between in vitro and in vivo?

 Yuichi Sugiyama (Sugiyama Laboratory, RIKEN Innovation Center) 

15:25-15:55

Analysis of nonlinear pharmacokinetics of highly albumin-bound compound 

Yukina Fukuchi (Ono Pharmaceutical Co., Ltd.) 

15:55-16:15

Coffee break

16:15-16:45      

Transporter targeted proteomics: applications and limitations

 Kimoto Emi (Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc.)

 

16:45-17:15

Prediction of Kp,uu of organic anions in hepatocytes considering the effect of the membrane potential

Takashi Yoshikado (Sugiyama Laboratory, RIKEN Innovation Center)

17:15-17:45         

Potential of computer based “Virtual Clinical Study”; physiologically-based pharmacokinetic modeling for CPT-11 and its metabolites as a model case

Kota Toshimoto (Sugiyama Laboratory, RIKEN Innovation Center)

17:45-18:15

Precise estimation of fm and Ki values for the prediction of CYP-mediate

drug interactions by the use of Cluster Newton Method

 Kazuya Maeda (The University of Tokyo)

18:15-18:30         

Concluding remarks

Yuichi Sugiyama (Sugiyama Laboratory, RIKEN Innovation Center) 

18:30-20:00

Banquet (Cafeteria at Yokohama RIKEN

 

 

Contact to:Sugiyama's Laboratory
Email: info [at] riken‐sugiyama.jp
HP: http://www.sugiyamalab.com/
Tel: 045‐503‐9210