THE 9th Sugiyama Laboratory Open Symposium

”New approaches for improving the accuracy of predictions of pharmacokinetic and toxicities of new drug candidates”

Date:Feb 24 13:50-17:50, 2017

Place: RIKEN Yokohama Main Building Hall 

Language:English

Registration Fee: Symposium Free, banquet 3,000yen

 

Registration ; mail to  info [ at ] riken‐sugiyama.jp with below information.

 

 name/affiliation/mail address/banquet(attend or not)

 

 

 

This Symposium is a part of the RIKEN Symposium Series.

 

 

Program

THE 9th RIKEN OPEN SYMPOSIUM_PROGRAM.pdf
PDFファイル 51.0 KB

13:50-13:55

 

Opening remarks

Yuichi Sugiyama (Sugiyama Laboratory, RIKEN Innovation Center) 

13:55-14:35

 

 

Effect of genetic polymorphism of BCRP on the pharmacokinetics/pharmacodynamics of drugs

Yuichi Sugiyama (Sugiyama Laboratory, RIKEN Innovation Center)

14:35-15:05

  

Effect of albumin on the hepatic uptake / pharmacokinetics of highly bound drugs

Seiji Miyauchi (Toho University)

15:05-15:35 

 

 

Prediction of the Clinical Risk of Drug-Induced Cholestatic Liver Injury Using an In Vitro Sandwich Cultured Hepatocyte Assay 

Kousei Ito (Chiba University)

15:35-15:55

Coffee break

15:55-16:25  

 

 

   

Quantitative prediction of hepatic uptake clearance mediated by organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 using relative activity factor-based scaling approach

Yoshitane Nozaki (Eisai Co., Ltd.)

16:25-16:55 

 

 

 

PBPK model of rifampicin incorporating its hepatic uptake and auto-induction process to predict various types of DDIs such as CYP3A/2C9 inductions and OATPs inhibitions

Ryuta Asaumi (Ono Pharmaceutical Co., Ltd.)

16:55-17:25 

 

 

     

PBPK model to investigate transporter-mediated disposition and clearance of metformin in humans Its application to the prediction of the effect of transporters related genetic polymorphism and DDI

Kotaro Nishiyama (Nippon Boehringer Ingelheim Co., Ltd.)

17:25-17:50         

Concluding remarks

Yuichi Sugiyama (Sugiyama Laboratory, RIKEN Innovation Center)

18:00-20:00

Banquet (Cafeteria at Yokohama RIKEN)

 

Contact to:Sugiyama's Laboratory
Email: info [at] riken‐sugiyama.jp
HP: http://www.sugiyamalab.com/
Tel: 045‐503‐9210