THE 9th Sugiyama Laboratory Open Symposium
”New approaches for improving the accuracy of predictions of pharmacokinetic and toxicities of new drug candidates”

Date:Feb 24 13:50-17:50, 2017
Place: RIKEN Yokohama Main Building Hall
Language:English
Registration Fee: Symposium Free, banquet 3,000yen
Registration ; mail to info [ at ] riken‐sugiyama.jp with below information.
name/affiliation/mail address/banquet(attend or not)
This Symposium is a part of the RIKEN Symposium Series.
Program
13:50-13:55
|
Opening remarks Yuichi Sugiyama (Sugiyama Laboratory, RIKEN Innovation Center) |
13:55-14:35
|
Effect of genetic polymorphism of BCRP on the pharmacokinetics/pharmacodynamics of drugs Yuichi Sugiyama (Sugiyama Laboratory, RIKEN Innovation Center) |
14:35-15:05
|
Effect of albumin on the hepatic uptake / pharmacokinetics of highly bound drugs Seiji Miyauchi (Toho University) |
15:05-15:35
|
Prediction of the Clinical Risk of Drug-Induced Cholestatic Liver Injury Using an In Vitro Sandwich Cultured Hepatocyte Assay Kousei Ito (Chiba University) |
15:35-15:55 |
Coffee break |
15:55-16:25
|
Quantitative prediction of hepatic uptake clearance mediated by organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 using relative activity factor-based scaling approach Yoshitane Nozaki (Eisai Co., Ltd.) |
16:25-16:55
|
PBPK model of rifampicin incorporating its hepatic uptake and auto-induction process to predict various types of DDIs such as CYP3A/2C9 inductions and OATPs inhibitions Ryuta Asaumi (Ono Pharmaceutical Co., Ltd.) |
16:55-17:25
|
PBPK model to investigate transporter-mediated disposition and clearance of metformin in humans Its application to the prediction of the effect of transporters related genetic polymorphism and DDI Kotaro Nishiyama (Nippon Boehringer Ingelheim Co., Ltd.) |
17:25-17:50 |
Concluding remarks Yuichi Sugiyama (Sugiyama Laboratory, RIKEN Innovation Center) |
18:00-20:00 |
Banquet (Cafeteria at Yokohama RIKEN) |
Contact to:Sugiyama's Laboratory
Email: info [at] riken‐sugiyama.jp
HP: http://www.sugiyamalab.com/
Tel: 045‐503‐9210